msi slotOne M.2 and PCIe x16 slot will always go through the CPU. If you use the other M.2 slot or any other PCIe slot, it goes through the chipset. Though depending on the board, II have installed the Samsung SM951 M.2 drive in my MSI SLI Plus motherboard as a boot drive. But in the MSI Guard Pro BIOS, there are a couple settings that are confusing